The role of different serotypes and dengue virus concentration in the prognosis of dengue shock syndrome in children

  • Tram Van Ta Tien Giang General Hospital, Tien Giang province, Vietnam
  • Hai Thanh Tran Tien Giang Medical College, Tien Giang province, Vietnam
  • Quyen Nguyen Than Ha Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
  • Xuong Tuyet Nguyen Vietnam National Hospital of Pediatrics, Hanoi, Vietnam
  • Vu Kien Tran Tra Vinh General Hospital, Tra Vinh province, Vietnam
  • Hien The Pham Tra Vinh University, Tra Vinh province, Vietnam
  • Cameron Simmons Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

Abstract

Dengue haemorrhagic fever (DHF) is a burden of disease in tropical countries, caused by any one of four-dengue virus (DENV) serotypes (DENV-1 to DENV-4). Although there have been many studies on patients with DHF, many things remain unclear, including the role of DENV serotypes and DENV concentration. The objective of this study was to determine the role of different serotypes and DENV concentration in the prognosis of dengue shock syndrome. This was a prospective cohort study, conducted to show information relating to patients’ conditions, such as hematocrit, platelet, leukocytes, and DENV concentration and the differences between DENV serotypes. The study also expressed the relationship between two groups, DHF without shock and DHF with shock, in terms of immune status, different DENV serotypes, and DENV concentration. Two-hundred and thirty-four patients were serologically confirmed as having a DENV infection. On hospital admission day (fever within 72 hours), results showed that almost all patients had a secondary dengue infection (76.5 %). DENV-1 accounted for the highest number of cases (61.11%), and DENV-4 accounted for the lowest (0.43%). No statistically significant difference was found when comparing the two groups (DHF with shock and DHF without shock) or when comparing the groups of different DENV serotypes. The study concluded that different DENV serotypes or DENV concentration in the first day of hospitalization (fever within 72 hours) cannot be used for prognostic of DSS.

Keywords: Dengue, DHF, Shock syndrome, Serotype, Vietnam

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Published
2019-08-09
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How to Cite
Tram Van Ta, Hai Thanh Tran, Quyen Nguyen Than Ha, Xuong Tuyet Nguyen, Vu Kien Tran, Hien The Pham, & Cameron Simmons. (2019). The role of different serotypes and dengue virus concentration in the prognosis of dengue shock syndrome in children. International Journal of Research in Pharmaceutical Sciences, 10(3), 2552-2557. https://doi.org/10.26452/ijrps.v10i3.1509
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Original Articles
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