Inhibitory role of Metformin for tamoxifen induced ‎uterine cell proliferation in diabetic ‎patients with ER-‎positive Breast cancer

  • Ghasak Kais Abd-Alhussain Department of pharmacology, College of Medicine, Baghdad University, Baghdad, Iraq
  • Mohammed Qasim Yahya Mal-Allah Al-Atrakji Department of Pharmacology, College of ‎Medicine, University ‎of Baghdad, Iraq
  • Wieeam Abdulfattah Saleh Department of Radiation Oncology, Oncology Teaching Hospital, Ministry of Health/ ‎Environment, Baghdad, Iraq
  • Aqeel Shaker Mahmood College of Medicine, Baghdad University, Iraq.

Abstract

The objective of the current work to evaluate the role of metformin in inhibiting the tamoxifen induced ‎endometrial ‎changes in diabetic patients with ER-positive breast cancer, a case-control study, carried out between December 2018 to May 2019, forty ‎diabetic women in postmenopausal phase with ER+ breast cancer on tamoxifen (20mg/day), ‎metformin ‎‎(1700 mg/day) GROUP A, and 40 diabetic patients with ER+ breast cancer on the ‎same dose of tamoxifen, but other hypoglycemic agent GROUP B, were selected as controls. ‎Uterine thickness was assessed by ultrasonography imaging at the beginning of treatment with ‎tamoxifen and after 2 years of treatment. Hysteroscopy ‎was done, and pathological findings also ‎recorded.‎ Mean uterine thickness of diabetic patients on other hypoglycemic was ‎significantly higher than diabetic patients on metformin (14.79±3.6 vs 4.37±1.8). Uterine ‎thickness >5mm were 2 (5%) vs ‎36 (85%) reported with the diabetic patient on metformin and the ‎diabetic patient on ‎other oral hypoglycemic group. Three cases (7.5%) of the diabetic patients ‎on other hypoglycemic agent were developed uterine polyps, and one case (2.5%) of diabetic ‎patients on metformin were developed uterine polyps. One case (2.5%) of uterine carcinoma ‎was reported with diabetic patients on other hypoglycemic group.‎ In conclusions metformin significantly inhibit tamoxifen-induced endometrial changes and ‎offers favorable endometrium protection.

Keywords: Metformin, tamoxifen, endometrial thickness, uterine carcinoma, diabetic

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Published
2019-08-09
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Ghasak Kais Abd-Alhussain, Mohammed Qasim Yahya Mal-Allah Al-Atrakji, Wieeam Abdulfattah Saleh, & Aqeel Shaker Mahmood. (2019). Inhibitory role of Metformin for tamoxifen induced ‎uterine cell proliferation in diabetic ‎patients with ER-‎positive Breast cancer. International Journal of Research in Pharmaceutical Sciences, 10(3), 2538-2541. https://doi.org/10.26452/ijrps.v10i3.1506
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