Triazoles with long chain alkyl groups as a potential biological compounds

  • Salih Mahdi Salman Department of Chemistry, College of Medicine, University of Diyala, Iraq

Abstract

New series of four compounds was synthesized from multi hydroxyl group compounds such as methyl glycoside by coupling with long-chain alky propargyl ester ( C10, C12, C14 and unsaturated C18) via click chemistry after activation the hydroxyl at C6 position by chlorination with N-chlorosuccinimide NCS and functionalized with sodium azide NaN3. The chemical structures and the purity of the resulting triazoles derivatives was confirmed by elemental analysis (CHN) and spectroscopic analysis 1H NMR & 13C NMR. The biological activity for the target compounds was investigated, and they show good antibacterial and antifungal properties against some selected gram-posative and fungi, which make them suitable for medical applications.

Keywords: Triazole ring, click chemistry, biological activity, alkylation, esterification

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Published
2019-07-22
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How to Cite
Salih Mahdi Salman. (2019). Triazoles with long chain alkyl groups as a potential biological compounds. International Journal of Research in Pharmaceutical Sciences, 10(3), 2334-2341. https://doi.org/10.26452/ijrps.v10i3.1475
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Original Articles
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