Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model

  • Sankaran PK Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India
  • Gunapriya Raghunath Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
  • Joy Ghoshal Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India
  • Yuvaraj Maria Francis Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
  • Siva T Department of Anatomy, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu, India
  • Kumaresan M Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
  • Karthikeyan Department of Anatomy, Saveetha Institute of Medical and Technical Sciences (Deemed University), Thandalam, Chennai-602 105, Tamil Nadu, India
  • Nandha Kumar Department of Anatomy, AIIMS, Mangalagiri-52008, Andhra Pradesh, India

Abstract

Migraine, a major public health problem, occurring due to the consequences of serial changes in the nerve ganglion leading to an imbalance in the excitation and inhibition. The is the major neurotransmitter in the central nervous system, causing to the sensory neurons leading to sensitization and . The present study was done to determine the effects of on the Nr2B of NMDA receptors after inducing a migraine. The rats were treated with after inducing migraine with nitroglycerin 10mg/kg. The nitroglycerin treated rats showed intense staining for NR2B , and there was a decrease in the expression after treatment. This study concludes that the NR2B are during migraine and can be used to control those by its property.

Keywords: Migraine, Riluzole, Glutamate, Headache, NMDA

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Published
2019-07-18
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How to Cite
Sankaran PK, Gunapriya Raghunath, Joy Ghoshal, Yuvaraj Maria Francis, Siva T, Kumaresan M, Karthikeyan, & Nandha Kumar. (2019). Effects of Riluzole on Nr2B subunits of NMDA receptors in rat migraine model. International Journal of Research in Pharmaceutical Sciences, 10(3), 2242-2245. https://doi.org/10.26452/ijrps.v10i3.1458
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Original Articles
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