Design and in vitro characterization of Amoxicillin loaded sepia nanoparticles

  • S. Ramesh Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India
  • D. Ranganayakulu Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India
  • D. Ranganayakulu Annamacharya college of Pharmacy, New boyanapalli, Rajampeta, Kadapa, Andhra Pradesh, India
  • K. Mallikarjuna Rao Annamacharya college of Pharmacy, New boyanapalli, Rajampeta, Kadapa, Andhra Pradesh, India
  • K. Gnanaprakash Annamacharya college of Pharmacy, New boyanapalli, Rajampeta, Kadapa, Andhra Pradesh, India
  • V. Shanmugam Sri Padmavathi School of Pharmacy, Thiruchanoor, Tirupathi, Andhra Pradesh, India

Abstract

The objective of the present work was to investigate the preparation of sepia nanoparticles as a potential drug carrier, amoxicillin Trihydrate as a model drug. The sepia nanoparticles were prepared by using the controlled gellification process. In this research work, different drug and polymer ratios were used. The prepared nanoparticles were evaluated to assess the various parameters such as drug content analysis, particle size analysis (SEM Analysis), Zeta potential analysis, In-Vitro drug release and stability studies. The particle size of prepared nanoparticles was found to be 500nm. The drug content analysis of all the prepared formulations was estimated in the range of 57.34 ± 0.10 to 65.33 ± 0.11 %. The zeta potential of the sepia nanoparticles was estimated as 69mv. The Cumulative percentage drug release of the third formulation was found to be 90.36 %. By observing in- Vitro drug release results of all formulations, we concluded that, AMN3 formulation was found to be the best formulation with a higher Cumulative percentage drug release.

Keywords: Amoxycillin, Sepia nanoparticles, Zeta Potential analysis, SEM Analysis, Particle size, U.V.Spectroscopic analysis

Downloads

Download data is not yet available.
Published
2010-01-05
Citations
How to Cite
S. Ramesh, D. Ranganayakulu, D. Ranganayakulu, K. Mallikarjuna Rao, K. Gnanaprakash, & V. Shanmugam. (2010). Design and in vitro characterization of Amoxicillin loaded sepia nanoparticles. International Journal of Research in Pharmaceutical Sciences, 1(1). Retrieved from https://pharmascope.org/index.php/ijrps/article/view/144
Section
Original Articles
Article Level Metrix
Abstract Views: 4
PDF Downloaded: 2          

Most read articles by the same author(s)