Reduce the toxicity of prepared copper sulfide nanoparticles

  • Manar M. Rashed Department of Applied Science, Biotechnology, University of Technology, Baghdad, Iraq
  • Nada H.A. Al-Mudallal Department of medical microbiology, College of Medicine, Al-Iraqia University, Baghdad, Iraq
  • Ali A. Taha Department of Applied Science, Biotechnology, University of Technology, Baghdad, Iraq

Abstract

Copper sulfide (CuS) nanoparticles have attracted increasing attention from biomedical ‎researchers across the globe, because of their intriguing properties, which have been ‎mainly explored for energy and catalysis related applications. The aim of the study is to ‎prepare CuS NPs by BSA entrapment to reduce the toxicity, characterizing, comparative ‎the toxicity before and after entrapment against bacteria and check the toxicity against RD ‎and L20B cell lines. CuS-BSA NPs was an easy, low toxicity and low cost chemically ‎synthesized. The CuS-BSA NPs was identified though UV-VIS ‎spectrophotometer, FTIR, XRD, SEM, EDX, and Zeta potential. The antibacterial activity ‎against different G-positive and G-negative bacterial strains have been investigated for (2 ‎mg/ml) concentrations of CuS-BSA NPs and commercial CuS. A result showed that CuS-‎BSA NPs have more antibacterial activity than commercial CuS. Using different ‎parameters of CuS-BSA NPs, its anti-cancer bioactivity for every compound synthesized in ‎RD and L20B cell line was explored, and the result proved there was significant toxicity ‎against RD and L20B cell lines.‎

Keywords: Copper sulfide, CuS-BSA, Nanoparticles, Antibacterial, Anticancer, RD cell line, L20B cell line

Downloads

Download data is not yet available.
Published
2019-07-12
Citations
How to Cite
Manar M. Rashed, Nada H.A. Al-Mudallal, & Ali A. Taha. (2019). Reduce the toxicity of prepared copper sulfide nanoparticles. International Journal of Research in Pharmaceutical Sciences, 10(3), 2099-2103. https://doi.org/10.26452/ijrps.v10i3.1433
Section
Original Articles
Article Level Metrix
Abstract Views: 16
PDF Downloaded: 10           LaTeX Downloaded: 2           HTML Downloaded: 0