synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients.

  • Israa N. Witwit University of Kufa, Factualy of Science, Department of Chemistry, Najaf, Iraq
  • Husham M. Mubark University of Kufa, Factualy of Science, Department of Chemistry, Najaf, Iraq
  • Hutham Mahmood Yousif Al-Labban University of Kufa, Factualy of Science, Department of Chemistry, Najaf, Iraq
  • Ahmed abduljabbar jaloob aljanaby University of Kufa, Faculty of Science, Department of Biology, Iraq

Abstract

New imidazole  azo ligand (DPIDA) was prepared by coupling reaction between 4,5-di phenyl imidazole and N1,N1-dimethylbenzene1,4-diamine di hydrochloride  and studied the complexation of this ligand with Mn(II) , Co(II) , Ni(II) , Cu(II) , Zn(II) , Cd(II) , and Hg(II)  ions , The free ligand and it’s complexes  characterized by Mass, 1HNMR, IR, UV-Vis. ,  and molar conductivity that indicated the octahedral geometry of them with a bidentate ligand which coordinated from (N3) atom of imidazole ring and one nitrogen atom of azo group.Biological activity of ligand (DPIDA) and it's complexes tested against two multi-drug resistant aerobic pathogenic bacteria isolated from patients with a burn. Three concentrations were selected (50, 100, 150) mg/ml for each crud synthesized derivative compounds. The derivative compound (4,5-diphenyl imidazole) with concentration 150mg/ml had an excellent antibacterial effect against Staphylococcus aureus and Pseudomonas aeruginosa with inhibition zone 21.83 ± 0.1764 mm and 24.30 ± 0.4163 mm respectively.

Keywords: imidazole azo, metal complexes, burn patients, biological activity, Staphylococcus aureus, Pseudomonas aeruginosa

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Published
2019-07-12
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How to Cite
Israa N. Witwit, Husham M. Mubark, Hutham Mahmood Yousif Al-Labban, & Ahmed abduljabbar jaloob aljanaby. (2019). synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients. International Journal of Research in Pharmaceutical Sciences, 10(3), 1847-1856. https://doi.org/10.26452/ijrps.v10i3.1382
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Original Articles
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