Anticancer potential of the extract of Melothoria maderaspatana on DMH induced colon cancer in albino rats

  • Ramachandran K Department of Pharmacy, College of Medical Sciences, Chitwan District – 44200, Nepal
  • Venketnarayanan R Department of Pharmacology, R. V. S. College of Pharmaceuticals Sciences, Coimbatore 641402, Tamil Nadu, India

Abstract

Cancers of the large and small intestine are major contributors to worldwide cancer morbidity and mortality. Out of all the cancers, colon cancer is one of the most common diseases in the world. Every year 1.2 million patients are diagnosed for colon cancer. The rate of colon cancer incidence was low in India but is presently increasing; out of 3.5 million cancer cases, 35,000 have colon cancer. As a part of chemotherapy, lots of anticancer drugs are in the market, but the main problem associated with these drugs is their side effects. Because of chemotherapy treatment side effects, the patient needs secondary palliative care treatment. Plant medicines are well known for their non-toxic side effects, so the objective of the study is to develop a drug from medicinal plant against colon cancer with non-toxic side effects. It plays an important role in the discovery of lead compound for the development of conventional drugs. About 60% of currently used anticancer agents are derived from a natural source. In the present study, Melothoria maderaspatana was used to study the anticancer potential of the extract and to synthesize new anticancer moiety. With the findings of the study, it can be concluded that the plant Melothoria maderaspatana and possess anti-colorectal cancer activity. Before the clinical usage of extract, thorough toxicological profile has to be determined on the crude extracts as well as on isolated compounds to confirm the safety of the drug.

Keywords: Melothoria maderaspatana, colon cancer, chemotherapy, herbal medicine

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Published
2019-07-12
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How to Cite
Ramachandran K, & Venketnarayanan R. (2019). Anticancer potential of the extract of Melothoria maderaspatana on DMH induced colon cancer in albino rats. International Journal of Research in Pharmaceutical Sciences, 10(3), 1770-1777. https://doi.org/10.26452/ijrps.v10i3.1370
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Original Articles
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