Serological markers of autoimmunity in women with polycystic ovary syndrome
In the present study, we evaluate the serum level of common autoimmunologic markers in women with polycystic ovary syndrome (PCOS) and study their relationship with hormonal parameters. The study was an observational case-control study, done in a Tertiary referral hospital, the study included 50 women with polycystic ovary syndrome and 50 matched control. Serum levels of Antinuclear Antibody (ANA) and anti-double-stranded DNA (dsDNA) were significantly higher in polycystic ovary syndrome women compared to control. Also, luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH ratio were significantly higher in polycystic ovary syndrome women compared to control. dsDNA had excellent ability to differentiate PCOS from control (AUC=0.901) while ANA had good discrimination ability (AUC=0.809). There was a significant direct relationship between ANA, dsDNA, and TSH with FSH in PCOS women, also a significant direct relationship between ANA and TSH with LH, while DsDNA did not correlate with LH. In conclusion, there is a clear relationship between immunological markers (ANA, dsDNA) with polycystic ovary syndrome in various components of the disease, dsDNA offer better ability than ANA as a predictor of PCOS, indicating that dsDNA can be used as a non-invasive diagnostic tool for PCOS.
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