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Entada rheedi is claimed to have antistress activity by folklore which is available abundantly in several places of India. The present study was planned to evaluate the phytochemical, anti-oxidant, anti-stress and cerebroprotective activities of ethyl acetate extract of bark of Entada rheedi (EAER). The bark of Entada rheedi was collected and extracted with ethyl acetate. The ethyl acetate extract was subjected to phytochemical screening (chemical and HPTLC), antioxidant (in-vitro), anti-stress (mice model) and cerebroprotective activities (cerebral ischemia model). EAER showed the presence of flavonoids as primary phytoconstituents. EAER significantly reduced the immobility time in swimming endurance and tail suspension test. EAER significantly reduced the TBARS levels and augmented tissue antioxidants in restraint stress model and cerebral ischemia model. The levels of MOA-A were reduced in the EAER treated animals and cortisol levels also reduced in EAER treated animals. Histopathology also supported the biochemical parameters. The EAER effect was compared with reference standard diazepam and Ashwagandha. EAER showed significant antioxidant, anti-stress and cerebroprotective activities and the protective effect could be due to the presence of flavonoids as phytoconstituents.
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