Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release

  • Harish Choodappa Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-641 004, Tamil Nadu, India
  • Subramanian Somaskandan Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-641 004, Tamil Nadu, India

Abstract

In this study, we aimed to prepare bilayer tablets of Glimepiride in floating drug delivery and Metformin in sustained release formulation. Glimepiride is chosen in floating drug delivery to overcome the gastric irritation and gastric emptying time. Glimepiride was prepared by different polymers such as guar gum, xanthan gum, carbopol and sodium bicarbonate act as effervescent agent, and other excipients were mixed and compressed by direct compression as the first layer.  Metformin was chosen in sustained release to reduce dose frequency using different polymer HPMC K100M, methylcellulose, PVP K30 in different ratio and other excipients were mixed and compressed as the second layer. The first layer and second layer are combined as a bilayer tablet. Tablets were evaluated for hardness, friability, thickness, weight variation; the In vitro studies were done for all formulation. Among all formulation, F2 was selected as best formulation and release kinetics studies were evaluated for formulation F2.

Keywords: Glimepiride, Metformin, Bilayer tablet, Floating tablet, Sustained release tablet

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Published
2019-07-12
Citations
How to Cite
Harish Choodappa, & Subramanian Somaskandan. (2019). Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release . International Journal of Research in Pharmaceutical Sciences, 10(3), 1602-1607. https://doi.org/10.26452/ijrps.v10i3.1319
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Original Articles
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