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Insilco technique in chemistry plays a major role in the development of new lead molecules. Computational tools docking, virtual screening, ADMET prediction are untilised in the identification of new lead molecules. A series of new benzofuranone derivatives IVA-F, containing a heterocyclic substituent linked to benzofuranone nucleus at C-2 were synthesized as potential antitumor agents. These products were synthesized starting with benzene 1.4 diol. The structures of all compounds were established on the basis of analytical and spectral data. The synthesized compounds were tested against human skin carcinoma cell line (G361) and all were found to be more potent of which compound IV B and IV F was the most active.


ADMET Anti cancer activity G361 cell line Sulforhodamine assay

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Raghava Doonaboyina, Abhilasha Mittal, & Sridhar Babu Gummadi. (2019). Insilco screening, and Synthesis of 5-hydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives as novel potent leads as anti-cancer agents. International Journal of Research in Pharmaceutical Sciences, 10(1), 710-720. Retrieved from