Synthesis and evaluation of antioxidant activities of novel quinazolin derivatives

  • Walaa. S. El-serwy Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
  • Neama. A. Mohamed Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
  • Weam. S. El-serwy Microbial and natural products chemistry department, National Research Centre, Dokki, Giza, Egypt
  • Emad. M. M. Kassem Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
  • Khaled Mahmoud Department of Pharmacognosy, National Research Centre, Giza 12622, Egypt

Abstract

Different acid chlorides 2a-c are used as starting material of a number of 2-(substituted)-4H-3,1-benzoxazin-4-one derivatives 3a-c, Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (MCF7-HePG2–HCT116).

Keywords: Quinazolin, benzoxazin, cytotoxic activity

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Published
2015-01-25
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How to Cite
Walaa. S. El-serwy, Neama. A. Mohamed, Weam. S. El-serwy, Emad. M. M. Kassem, & Khaled Mahmoud. (2015). Synthesis and evaluation of antioxidant activities of novel quinazolin derivatives. International Journal of Research in Pharmaceutical Sciences, 6(1), 62-74. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/1218
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Original Articles
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