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Abstract

Pollution is a worldwide environmental problem that affects our environment in a wide range. These pollutants causes a great variety of health problems. Among them, toxic metals play an important role. The one comnmon toxic metal is cadmium. Curcumin (diferuoyl methane) is a well-knowm biologically active compound in tumeric derived from the rhizome of plant curcuma longa . curcuma longa is a gold coloured spice most commonly used in food as colouring agent and also for preservation of food. The aim of our present study was to evaluate the toxicity nature of cadmium acetate and antioxidant capacity of curcumin on liver injury in albino mice. The animals were randomly divided into four groups, each with six animals. Group I (control group) received normal feed, Group II was administered with cadmium acetate (200 mg/kg) dissolved in water, Group III was administered only with curcumin and Group IV received a dose of 250 mg/kg of curcumin and 200 mg/kg of cadmium acetate. The experiment was conducted for the period of 7 days. Rats treated with cadmium acetate alone showed a increased activity of ALT, AST and a decreased activity of ALP, Protein concentrartion in serum. And also a marked decline in antioxidant enzymes like Superoxide dismutase and Catalase in cadmium acetate induced rats. However, on combined treatment of rats with curcumin and cadmium acetate provoked the above changes more significantly, when compared to each of them as alone. Hence it is suggested that curcumin has a protective effect against a cadmium acetate induced hepatic injury.

Keywords

Antioxidant enzymes Cadmium acetate Curcumin Hepatotoxicity

Article Details

How to Cite
Deevika B, Asha S, Taju G, & Nalini T. (2012). A study of cadmium acetate induced toxicity and heptoprotective activities of curcumin in albino rats. International Journal of Research in Pharmaceutical Sciences, 3(3), 436-440. Retrieved from https://pharmascope.org/ijrps/article/view/1060