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The anti-inflammatory effect of the Pet ether and aqueous leaf extract of Parkinsonia acculeata was evaluated using the carrageenan and formalin induced rat paw edema. The extract administered orally at 500 mg/kg b. w produced a significant inhibition. The results obtained suggest that the Pet ether and aqueous leaf extract of Parkinsonia acculeata is endowed with effective anti-inflammatory activity mediated via either inhibition of cyclo-oxygenase pathways, inhibiting the synthesis of inflammatory mediators and scavenging free oxygen radicals. These findings seem to justify that the plant can be used as an anti-inflammatory agent.
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