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The present objective of the work is to investigate the efficiency of freshly extracted natural mucoadhesive materials Caesalpinia pulcherrima (NMM01) and Leucaena leucocephala (NMM02) were compared with synthetic and semi synthetic mucoadhesive polymers like hydro propyl cellulose (HPC) and sodium alginate respectively. The tablets were prepared by wet granulation method and followed by evaluation of granules and tablets were carried out by possible methods like, angle of repose, bulk density, tapped density, compressibility index and hausner’s ratios showed that the granules good to compress, gelling and mucoadhesive strength of natural materials were studied by swelling index and ex vivo methods, NMM01 was showed more adhesion, 0.1535 neutons at 30 minutes of time, greatest retardation of drug release was observed. In vitro drug release mechanism was found out by fitting the cumulative percentage drug release against time in hours to higuchi, Korsmeyer-Peppa’s first and zero order. The drug release studies reveals that best formulation was follows non-fickian diffusion, due to erosion of the matrices. There is no significant difference in drug release between the marketed sustained release product and natural mucoadhesive materials incorporated best formulation.
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