Formulation and evaluation of low cost sustained release floating alginate beads

  • Venkateshwar Reddy A Anwarul Uloom college of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
  • Sairam Maduri Anwarul Uloom college of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India

Abstract

Floating beads are the micro-beads/ spheres prepared by ionic gelation technique. They can be either of sustained release or immediate release type. Sustained release type of floating drug delivery systems generally employ a high viscosity polymer like the hydroxyl propyl methyl cellulose (HPMC) or ethyl cellulose as the matrixing agent. These polymers are generally very expensive, and their use in the formulation leads to increased cost of the formulation, which is the main reason that limits the wide-spread usage of this dosage form. In this study, we have tried to produce low cost floating alginate beads by substituting high-cost polymers like HPMC with low cost polymer like carboxy methyl cellulose (CMC). Comparative studies were carried out to determine the efficacy of formulations containing CMC with that of formulations containing HPMC as the matrixing agent. We have also studied the effect of physicochemical properties of the drugs on the drug release pattern of the dosage form i.e. floating alginate beads.

Keywords: Floating Beads, Hydroxy propyl methyl cellulose, Sodium Alginate, Counter ion effect, Carboxy methyl cellulose, Clarithromycin, Paracetamol, Aluminium Hydroxide

Downloads

Download data is not yet available.
Published
2012-07-25
Citations
How to Cite
Venkateshwar Reddy A, & Sairam Maduri. (2012). Formulation and evaluation of low cost sustained release floating alginate beads. International Journal of Research in Pharmaceutical Sciences, 3(3), 398-403. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/1053
Section
Original Articles
Article Level Metrix
Abstract Views: 11
PDF Downloaded: 7