Evaluation of diuretic activity of Delonix regia (Gul mohr) flowers in albino rats

  • Senthil Velan S Department of Pharmacology, S.Chaavan College of Pharmacy, Jangalakandriga (V), Muthukur (M), Nellore (Dt), Andhra Pradesh, India
  • Jeeva Prakash G Department of Pharmacology, S.Chaavan College of Pharmacy, Jangalakandriga (V), Muthukur (M), Nellore (Dt), Andhra Pradesh, India
  • Sindhan V Department of Pharmacology, C.L. Baid Mehta College of Pharmacy, Thorapakkam, Chennai, Tamil Nadu, India
  • Somasekhar E Department of Pharmacology, S.Chaavan College of Pharmacy, Jangalakandriga (V), Muthukur (M), Nellore (Dt), Andhra Pradesh, India
  • Bharathi S Department of Pharmacology, S.Chaavan College of Pharmacy, Jangalakandriga (V), Muthukur (M), Nellore (Dt), Andhra Pradesh, India
  • Rajani B Department of Pharmacology, S.Chaavan College of Pharmacy, Jangalakandriga (V), Muthukur (M), Nellore (Dt), Andhra Pradesh, India

Abstract

The Diuretic activity of Delonix regia (Gul Mohr) flower extract was evaluated by Lipschitz test model in Albino rat. The animals were divided into four groups. Group I serving as control, received normal saline (25ml/kg,p.o), the group II received methanolic extract (100mg/kg,p.o) and group III also received methanolic extract (200mg/kg,p.o), the group IV received Furosemide (20mg/kg,p.o), respectively, in normal saline. Immediately after the administration, the animals were kept in metabolic cages (3 per cage) specially designed to separate urine and fecal matter and kept at room temperature of 25 ± 0.5°C throughout the experiment. The volumes of urine, urinary concentration of sodium, potassium and chloride ions were the parameters of the study. The results indicate that methanol extract at a concentration of 100 mg/kg and 200 mg/kg body weight shows an increase in the urine volume and electrolyte excretion when compared to control. Thus, the methanol extract of the flower of Delonix regia (Gul Mohr) showed a significant diuretic activity. From the present study, it may be concluded that the phytoconstituents present in methanol extract may be responsible for diuretic activity.

Keywords: Delonix regia (Gul Mohr), Electrolyte excretion, Furosemide, Lipschitz test model, Metabolic cages

Downloads

Download data is not yet available.
Published
2012-07-25
Citations
How to Cite
Senthil Velan S, Jeeva Prakash G, Sindhan V, Somasekhar E, Bharathi S, & Rajani B. (2012). Evaluation of diuretic activity of Delonix regia (Gul mohr) flowers in albino rats. International Journal of Research in Pharmaceutical Sciences, 3(3), 369-372. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/1048
Section
Original Articles
Article Level Metrix
Abstract Views: 26
PDF Downloaded: 16