Formulation and in vitro comparative evaluation of orodispersible tablets of Granisetron hydrochloride
In the present work, an attempt has been made to formulate oral dispersible tablets of granisetron HCl by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Nine batches of tablets were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetic and stability studies. Formulations prepared by superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to formulations prepared by sublimation and effervescent methods. It was concluded that oral dispersible tablets of granisetron HCl can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.
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