Anticancer and antitubercular study of some 1,4-disubstituted [1,2,4]-triazolo[4,3-a] quinazolin-5(4H)-ones

  • Gobinath Manavalan Department of Pharmaceutical Engineering & Technology, Bharathidasan University, Tiruchirappalli - 620 024, India
  • Subramanian Natesan Department of Pharmaceutical Technology, Anna University of Technology Tiruchirappalli, Tiruchirappalli – 620 024, India
  • Alagarsamy Veerachamy Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Sangareddy, Gr. Hyderabad-502 294, India


In the present study, a series of 1-substituted-4-(2-methoxyphenyl)-[1,2,4]-triazolo[4,3-a]quinazolin-5(4H)-ones were screened for their anticancer activity and anti tubercular activity. In vitro anticancer activity was determined against cancer cell lines HT-29, Hep-G2 and Hela using MTT assay and in vitro antitubercular activity was studied by agar dilution method using Mycobacterium tuberculosis strain H37 Rv. Among the series of compounds, 1-chloromethyl-4-(2-methoxyphenyl)- [1,2,4]-triazolo[4,3-a]quinazolin-5(4H)-one showed moderate anti-cancer activity than other substituted quinazolin-5(4H)-ones. While, 1-ethyl-4-(2-methoxyphenyl)-[1,2,4]-triazolo [4,3-a] quinazolin-5(4H )-one and 4-(2-methoxyphenyl)-1-propyl-[1,2,4]-triazolo [4,3-a] quinazolin-5(4H )-one exhibited effective anti-tubercular activity with the MIC of 6.25 mg/mL.

Keywords: Quinazoline, Anticancer, Antitubercular, MTT assay, Agar Dilution Method


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Gobinath Manavalan, Subramanian Natesan, & Alagarsamy Veerachamy. (2012). Anticancer and antitubercular study of some 1,4-disubstituted [1,2,4]-triazolo[4,3-a] quinazolin-5(4H)-ones. International Journal of Research in Pharmaceutical Sciences, 3(1), 146-149. Retrieved from
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