Chemopreventive potential of chrysin in 7, 12-dimethylbenz(a)anthracene in-duced skin carcinogenesis in Swiss albino mice

  • Murugaraj Manoj Prabhakar Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India
  • Shanmugam Manoharan Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India
  • Nagarethinam Baskaran Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India
  • Ramachandran Srinivasan Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India
  • Sekar Karthikeyan Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India
  • Shamsul Afaq Wani Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai nagar – 608 002, Tamil Nadu, India

Abstract

Chrysin (5,7-dihydroxy flavone) possesses diverse pharmacological effects including anticancer potential. Aim of the present investigation was to assess the chemopreventive potential of chrysin in 7, 12-dimethylbenz (a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Skin tumors in mice were developed by painting with DMBA two times a week for 8 weeks. Hundred percent tumors was noticed in mice treated with DMBA alone after 14 weeks. Though oral administration of chrysin at a dose of 250 mg/kg bw to mice treated with DMBA significantly (86.6%) prevented tumor formation, severe hyperplasia, hyperkeratosis and dysplasia was noticed. The present results suggest that chrysin might have delayed rather than inhibiting the tumor formation during DMBA-induced skin carcinogenesis.

Keywords: Chemoprevention, DMBA, Skin cancer, Chrysin

Downloads

Download data is not yet available.
Published
2012-01-25
Citations
How to Cite
Murugaraj Manoj Prabhakar, Shanmugam Manoharan, Nagarethinam Baskaran, Ramachandran Srinivasan, Sekar Karthikeyan, & Shamsul Afaq Wani. (2012). Chemopreventive potential of chrysin in 7, 12-dimethylbenz(a)anthracene in-duced skin carcinogenesis in Swiss albino mice. International Journal of Research in Pharmaceutical Sciences, 3(1), 89-96. Retrieved from https://pharmascope.org/index.php/ijrps/article/view/1002
Section
Original Articles
Article Level Metrix
Abstract Views: 6
PDF Downloaded: 7