Chemopreventive potential of chrysin in 7, 12-dimethylbenz(a)anthracene in-duced skin carcinogenesis in Swiss albino mice
Chrysin (5,7-dihydroxy flavone) possesses diverse pharmacological effects including anticancer potential. Aim of the present investigation was to assess the chemopreventive potential of chrysin in 7, 12-dimethylbenz (a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. Skin tumors in mice were developed by painting with DMBA two times a week for 8 weeks. Hundred percent tumors was noticed in mice treated with DMBA alone after 14 weeks. Though oral administration of chrysin at a dose of 250 mg/kg bw to mice treated with DMBA significantly (86.6%) prevented tumor formation, severe hyperplasia, hyperkeratosis and dysplasia was noticed. The present results suggest that chrysin might have delayed rather than inhibiting the tumor formation during DMBA-induced skin carcinogenesis.
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