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Abstract

A simple chemo metrics-assisted spectrophotometric method for the determination of lansoprazole in capsule form is described. Lansoprazole is an active proton-pump inhibitor drug act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or, more common, gastric proton pump) of the gastric parietal cell. The UV absorption spectra of the studied drugs were in the range of 200-400 nm. The developed spectrophotometric method is simple, rapid, precise, accurate, reliable and economical when compared to other methods? The method was also applied for capsule formulations. It gives better results in terms of accuracy, precision and linearity over a range of 5- 25 µg/ml for lansoprazole. The limit of detection in capsule dosage form are 2µg/ml, the limit of quantification for capsule are 5µg/ml for pharmaceutical formulation. The % RSD is less than 49.19 %, and the recovery is 111 – 147 % as results the above method can be applied for bulk and finished product of lansoprazole.

Keywords

spectrophotometry PPI-drug proton pump inhibitors

Article Details

How to Cite
M.Alagar raja, Satish Kumar yadav, Amit rai, & Shuchita Mishra. (2011). Analytical estimation of lansoprazole and validation of simple spectrophotometric in bulk and capsule formulation. International Journal of Research in Pharmaceutical Sciences, 2(3), 521-524. Retrieved from https://pharmascope.org/ijrps/article/view/926