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Effective topical antimicrobial agents decrease bacterial colonization and infection. Localization of nitrofurazone into the eschar using vehicle such as solid lipid nanoparticles (SLN) improves antimicrobial efficiency in treatment of the infection in burn patients. This study was undertaken to develop solid lipid nanoparticles (SLN) of nitrofurazone using cold homogenization technique and study the permeability of the drug through rat skin. Results show type and percentage of surfactant, type of lipid and drug/lipid ratio can influence SLN character Drug release from SLN was the rate limiting step for drug permeation across rat skin and so prepared formulations can act as a drug reservoir.
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