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The purpose of this study was to develop and optimize formulations of mucoadhesive patches of Terbutaline sulphate. The patches were prepared by the solvent casting method using Hydroxyl propyl methyl cellulose(HPMC cps50) as basic polymer and Carbopol 934, Eudragit RL 100, and Ethyl cellulose were taken in various ratios and 6 different formulations were made. The patches were found to be smooth in appearance, uniform in thickness, weight uniformity, drug content, swelling behaviour, and surface pH. The BP3 formulation containing Terbutaline sulphate, HPMC: Eudragit RL100 (4:1) Glycerine, Acetone and Tween 80 showed a release of 96.36% after 12 hours in phosphate buffer (pH, 6.8). This formulation was further optimized by varying HPMC cps50 and Eudragit RL100 and other variables and 9 new formulations F1 to F9 were prepared. Among the nine formulation, F6 formulation showed maximum desired properties and release 96.89%.
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