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Abstract

Leaves of Canavalia rosea were shade dried, powdered and was extracted using nine solvents Ethanol, Methanol, Chloroform, Acetone, Benzene, Dichloromethane, Petroleum ether, Hexane and Aqueous. Preliminary phytochemical screening of the crude extracts revealed the presence of tannins, phlobatannins, saponins, flavonoids, alkaloids, cardiac glycosides and phenolics. The presence of these bioactive constituents is associated with the antimicrobial activity of the plant. Agar well diffusion method revealed high activity against microorganisms, Bacillus cereus; Bacillus megaterium; Bacillus stearothemophilus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis a group of gram- positive bacteria that frequently cause enteric infections in humans. Gram negative bacteria were not as susceptible as gram- positive bacteria. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranged from 0.03mg/ml to 2 mg/ml and 0.12 to 4 mg/ml respectively. The results confirm that C. rosea can be used as source of drugs to fight infections caused by susceptible bacteria.

Keywords

Canavalia rosea phytochemical methanolic extract ethanolic extract antibacterial activity MIC MBC

Article Details

How to Cite
S. Prabhu, L. Joelri Michael Raj, S. John Britto, & S.R. Senthilkumar. (2010). Antibacterial activity and Preliminary phytochemical analysis of leaf extract of Canavalia rosea (Sw.) DC. (Beach Bean). International Journal of Research in Pharmaceutical Sciences, 1(4), 428-434. Retrieved from https://pharmascope.org/ijrps/article/view/914