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The present work involved cyclization of imines by reaction with chloro-methylene chloride using 1, 4-dioxane as solvent (2a&2b). The imines were formed by reaction with furan-2-carboxyldehyde and various substituted heterocyclic amines (1a&1b). The cyclic derivatives were found to be associated with diverse antimicrobial activity.


Furfuraldehyde Imines Column chromatography Azetidines Antimicrobial

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Sandip Sen, Biplab De, T.S.Easwari, A.S.Nagarajan, & Sandeep Maurya. (2011). Cyclization of microbiologically active 4-(furan-2-yl)-1-(pyridine-4-yl)-azetidine-2-one derivatives. International Journal of Research in Pharmaceutical Sciences, 2(2), 183-186. Retrieved from