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The Parkinson disease is a slowly progressive, degenerative disease of the nervous system associated with damage of dopaminergic neurons in the brain. Though PD was mainly due to damage of damage of dopaminergic system, other neurotransmitters also effected during PD and contribute to non-motor symptoms of PD. The current study was undertaken to observe the effect of caloric vestibular stimulation on brain neurotransmitters in an MPTP-induced mouse model of Parkinson's disease. 24 healthy, adult male Swiss albino mice with body weight ranging between 25 - 40g were used in the study. The middle ear cavity of the mice was irrigated with hot (40°C) water. 0.5 ml of water was taken in 5 ml syringe with the needle removed. The ear was irrigated with water drop by drop, using the syringe. After 30 days of the experimental period, the animals were fasted overnight and sacrificed by cervical decapitation and neurotransmitter levels were estimated. The present study provides evidence for beneficial effects of caloric vestibular stimulation in limiting the changes in neurotransmitter levels in Parkinson's disease. We recommend further detailed studies in this area to understand the mechanism of action and to recommend vestibular stimulation as adjunctive therapy in the management of Parkinson's disease.