Evaluation of anti-epileptic activity of chloroform extract of Gossypium herbaceum leaves

Abstract

The present study was aimed to evaluate antiepileptic activity of chloroform extract of leaves of Gossypium herbaceum (CGH) in mice. The antiepileptic activity of CGH was evaluated in mice at 10, 30, and 100 mg/Kg, p.o. by using maximum electroshock (MES), Pentylenetetrazole (PTZ) and Isoniazid (INH)-induced convulsions in mice. Statistical analysis was carried out by one-way analysis of variance (ANOVA) followed by Dunnett’s t test. In MES and PTZ methods, CGH significantly protected mice from convulsions potent than Diazepam and Phenobarbitone sodium (PS). In INH method, CGH slightly delayed the onset of convulsions. It may be concluded that CGH exhibited significant and dose-dependent antiepileptic activity potent than Diazepam and PS.