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The objective of present study was to improve the aqueous solubility and dissolution rate of poorly water-soluble drug Atenolol by solid dispersion technique. The method of preparation used was Solvent Evaporation Method, using a hydrophilic carrier polyethylene glycol 6000 (PEG 6000). The study was further aimed to characterize prepared solid dispersions in the solid state by Fourier Transform Infrared Spectroscopy (FTIR), and Powder X-Ray Diffraction (PXRD) patterns. Dissolution Studies were carried out to find out percentage released content of drug as a function of time. UV Spectroscopy method was used to find out drug contents in all the samples.


Solid dispersion Atenolol PEG 6000 Dissolution Solubility

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How to Cite
Anu Mahajan, Simarpreet Singh, Satvinder Kaur, & Amit Aggarwal. (2013). Studies on solubility enhancement and In vitro dissolution profile of poorly water soluble drug Atenolol using solid dispersion technique. International Journal of Research in Pharmaceutical Sciences, 4(3), 344-349.