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Abstract

In the present study the methanol extract of Andrographis echioides (MEAE) against acetaminophen induced hepatotoxicity and anti-oxidant activity in Wistar albino rats was analyzed. The methanol extract of Andrographis echioides (200 and 400 mg/kg body weight) were administer orally to two groups of rats (six animals per group) in order to evaluate the protective effect of the extract in rats. The other three groups were received normal saline (2 ml/kg), acetaminophen (750 mg/kg), and silymarin (50 mg/kg) respectively. The anti-oxidant effect of the extract on serum marker enzymes and histopathological studies of liver was assessed. The plant extract (200 and 400 mg/kg, p.o.) showed a remarkable hepatoprotective and antioxidant activity against acetaminophen induced hepatotoxicity. Histopathological changes of liver sample shows mild hepatocyte degeneration. Results indicate that the A.echoides possesses significant hepatoprotective and antioxidant property. Thus, the study substantiates its use in traditional herbal medicine.

Keywords

Acetaminophen Andrographis echioides Antioxidants Biochemical parameters Histopathology

Article Details

How to Cite
Mani Rupeshkumar, Kunchu Kavitha, & Pallab Kanti Haldar. (2014). Protective efficacy of Andrographis echioides against paracetamol induced oxidative stress and cellular degeneration in rat liver. International Journal of Research in Pharmaceutical Sciences, 5(4). Retrieved from https://pharmascope.org/ijrps/article/view/660