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Chronic renal failure is associated with an extensive and complex set of pathological consequences that can result in a number of irreversible, but preventable complications affecting every organ of the body. Chronic renal failure is associated with insulin resistance, hypertension, and increased glycation of proteins, proteinuria, anaemia, cardiovascular diseases and hypothyroidism. Our aim of the study oxidative stress markers and inflammatory markers in chronic renal failure. Methods and Materials: the Present study was done at Fathima Institute of Medical Sciences, Kadapa. Andhra Pradesh. Thirty six chronic renal failure patients, 40 healthy individuals were taken for study. oxidative stress markers and inflammatory markers were estimated by different methods. Conclusion: In our study workprovidesthefirstevidencethatthedecreasedinphosphorylationofIRS-1inresponseto insulin stimulation in animal models of both oxidative stress and CRF could be the main culprit in causing insulin resistance. Further, alteration of redox sensitive stress kinases seems to have a major hand in decreasingIRS-1tyrosinephosphorylation.
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