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Bee venom is a complex mixture of proteins, peptides and low molecular components. Nowadays its components have been characterized, the therapeutic application of bee-venom has been well investigated against Gram-negative and Gram-positive bacteria. To determine antibacterial activity of bee venom against Multidrug-resistant Acinetobacter baumannii locally isolates. Bee venom was assessed for their antibacterial activity against four Multidrug-resistant Acinetobacter baumannii bacterial strains by using MIC depends on resazurin stain, well diffusion methods and Reactive Oxygen Species (ROS) generation test. The minimum inhibitory concentration (MIC) of BV were determined with values (31.25 mg/ml) and bee venom can inhibit the growth of MDR Acinetobacter baumannii and may be one of the killing mechanisms by Reactive Oxygen Species (ROS) production which lead to DNA destruction. Bee venom had antibacterial activities against MDR Acinetobacter baumannii which confirms the previous work that suggested that bee venom can inhibit growth and survival of some bacterial strains.
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