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Oranges, fruits are bioactive citrus fruits belong to the Rutaceae, family. At the beginning of this study, Phytochemical screened of dried oranges peels showed the absence of coumarins, saponins, sterols, terpenoids, anthraquinones and protein. While the presence of flavonoids, alkaloids, carbohydrate, glycosides, tannins, polyphenol. Afterwards, Hesperetin (flavanone) and hesperidins (flavanone glycoside) were extracted and isolated from dried oranges peels (citrus fruits) and characterized by FTIR spectra, TLC, melting point, Chemical test. In time antibacterial activity of Hesperetin and hesperidins studied against some pathogenic bacterial strains isolated from patients like Streptococcus, Acinetobacter, E.coli, Klebsiella, Staphylococcus, Aeromonas. Eventually, Hesperetin (flavanone) showed a Higher biological activity significant than hesperidins and cefuroxime drugs.
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