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Abstract

Gastro-retentive drug delivery systems (GRDDS) attributes to gastric maintenance time combined with the medication discharge for expanded time has essentially improved patient consistency. Medications for which the chief fundamental site of ingestion is the stomach or the proximal piece of the small digestive tract or have the assimilation issue in the distal piece of the digestive system are reasonable for GRDDS. Orally sustaining or controlling the drug release combined with gastric retention property can avoid  recurrent dosing in the case of drugs with short half-lives. GRDDS is also effective in locally treating gastric and duodenal ulcers, including oesophagitis and Helicobacter pylori  infections. In this current survey, the physiology of the stomach alongside its motility design, typically called migrating motor complex (MMC), was discussed. Various approaches to GRDDS  with a focus on floating drug delivery systems (FDDS) were reviewed. The vacillations in plasma drug focus are limited and portion subordinate unfriendly impacts can be forestalled by FDDS, particularly for the medications with a restricted restorative list. Slow arrival of the medication into the body by means of FDDS limits the counter movement prompting higher medication proficiency. Further, the Advantages, limitations, suitable drug candidates, factors affecting and Future challenges of FDDS were discussed.

Keywords

Gastro-retentive drug delivery systems migrating motor complex ϐloating drug delivery systems mucoadhesion raft forming systems effervescence

Article Details

How to Cite
Durga Srinivasarao M, Saravanakumar K., & Chandra Sekhar Kothapalli Bannoth. (2021). Gastro-retentive drug delivery systems: a review with focus on ϐloating drug delivery systems. International Journal of Research in Pharmaceutical Sciences, 12(2), 1330-1337. https://doi.org/10.26452/ijrps.v12i2.4684