Method Development and Validation of Ivacaftor in Bulk and Pharmaceu-tical dosage form by UV Spectrophotometry

Abstract

The easiest, precise, accurate means of analysis of the drug is by UV Spectrophotometry. In this regard, Ivacaftor drug is analyzed by method development and validation for UV spectrophotometric study. The linearity studies obeyed Beer and Lambert's law where the linear regression coefficient value was found to be 0.9973 at λmax 202nm. The linearity range considered for the present study being 1-5 μg/ml. The test validation parameters and the recovery value satisfy the acceptance criteria by the method developed. Therefore the present method developed can be used for routine analysis of Bulk product and formulated dosage forms of Ivacaftor.