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The aim of the current work was mainly to find the neuroleptic effects of responsible compounds isolated from Cassia occidentalis leaves, on condiontioning avoidance and catalepsy induced psychotic wistar rats. Psychosis was induced by condiontioning avoidance and catalepsy induced in albino wistar rats. An isolated fraction of the ethanolic extract of Cassia occidentalis was ingested orally at 100 mg/kg, p.o dose. Haloperidol was considered as standard neuroleptic drug (10 mg/kg, p.o.). The isolated fractions from the column chromatography showing for the higher neuroleptic activity that facilitated for isolating the pure constituent, that was named trivially as name CO- 1.Precise analysis of the previous investigations with Ethanolic extract of Cassia occidentalis (ETCO) have encouraged us to isolate anti-psychotic responsible consituents from the leaves of Cassia occidentalis for managing the anti-psychotic activity. Collected pooled fractions were subjected to anti-psychotic activity in conditioning avoidance and catalepsy induced wistar rats. The fraction F from ETCO showed strong neuroleptic activity when compared with the commercial standard drug Haloperidol. To propose the constituents that possess anti psychotic activity related to F respectively. Besides, column chromatography analysis was performed with ‘F’ using different solvents and the isolated compound which is named as CO-1. This amorphous powder was extracted from the column with decomposition point. CO-1 is a phenolic compound that was confirmed by IR, Mass Spectrum and NMR analysis.
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