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Abstract

Emergence and spread of new viral and bacterial originated infectious diseases along with mutated new strains posing enormous global challenges. Respiratory infection is one of the major concerns in the current and past situation. With the lack of a safe and effective vaccine and small molecules drugs for effective treatments there is a need of efficacious herbal medicine to tackle infectious diseases. The herbal treatments mentioned in the Ayurveda can be excellent source for an effective treatment. In the present study a hard- boiled candy formulation was from promising herbs recommended herbs from Ayurveda for respiratory health and immunmodulatory actions. The herbs selected were Ocimum sanctum-OS (leafs), Terminalia chebula-TC (fruit), Glycyrrhiza glabra-GG (roots), Curcuma longa-CL (rhizomes), Zingiber officinale-ZO (rhizomes), Piper longum-PL (fruits). The herbs were evaluated for antiviral and antibacterial activity. The results indicated that most of the extracts exhibited antimicrobial activity against pathogens B. subtilis, S.aureus, S.pyogens and S.pneumoniae and showed significant antiviral activity against DENV  virus in vitro. The formulated hard-boiled candy was found to be having satisfactory quality parameters of hardness, friability, and dissolving time. The HPTLC profile was developed for the candy formulation as an effective quality control tool. This study indicates that the hard-boiled candy (HBC) could be an ideal solid oral dosage form for herbal drug delivery at local region of oropharyngeal region.

Keywords

Ayurveda Herbal-Drugs Hard-Boiled Candy Formulation Antibacterial Antiviral

Article Details

How to Cite
Manas Ranjan Sahoo, Marakanam Srinivasan Umashankar, Ramesh Raghava varrier, & Paul Pandian. (2021). Development and evaluation of polyherbal based medicated candy from Ayurveda herbs reported for cough and cold and Evaluation of their anti-viral and anti-bacterial properties. International Journal of Research in Pharmaceutical Sciences, 12(1), 280-291. https://doi.org/10.26452/ijrps.v12i1.3990