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Vitamin D has been found to be one of the principal factors for women reproductive health with protective functions against different tumours. The present study design was aimed to investigate the serum concentrations of 25-hydroxyvitamin D (25(OH) D) and its role in the pathogenesis of breast cancer in Iraqi women. This case study included 38 Iraqi women diagnosed with primary breast cancer (BC). These women were classified according to their severity of BC into group 1 (number=12), group 2 (number=14), and group 3 (number=12). Investigations included serum measurements of 25-hydroxyvitamin D and CA 15-3 by using enzyme-linked immunosorbent assay (ELISA) technique. The study revealed that the mean (±SD) value of serum 25 (OH) D levels were observed to be (16.1±4.30 ng/ml) in the whole group of BC women. The mean value of vitamin D significantly decreased with an advanced stage of BC (p=0.001). The significant negative correlation was found between serum levels of vitamin D and serum levels of CA 15-3 (r=- 0.465, p= 0.003). This study concluded the significant role of vitamin D in the pathogenesis of BC and the progression of its severity. Vitamin D doses may be a benefit in the prevention and treatment of breast cancer.
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