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A vast number of biological properties have been recognised to Thiohydantoin derivatives, have attracted continuing interest because of their various biological activities, namely anticonvulsant, hypolipidemic activity, anti-thyroidal activity, and anti-microbial actions. In this look upon, multiple numbers of Thiohydantoin derivatives are synthesised besides anti-epileptic mechanisms have been investigated. A series of 3-substituted 2-thiohydantoin Derivatives were synthesised from Benzil via Benzil-Benzilic Acid Rearrangement, characterised and evaluated for their anti-epileptic activity by Maximal Electroshock Seizure (MES) model for the anti-epileptic activity of synthesised compounds was less when compared to standard. Among the activity, synthesised compounds 1 indicated more anti-epileptic activity. With this confirmation, we revised integrated a series of innovative 3-substituted 2-thiohydantoin derivatives with a different substituent on the construction and studied the structural activity relationship. The outcomes indicated with the purpose of all the tested compounds have displayed evident anti-epileptic activity. Among the series compounds, 1 shows more anti-epileptic activity than other synthesised compounds.


Anti-epileptic activity Benzil-benzilic acid rearrangement MES Thiohydantoin

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How to Cite
Prakash G, Mohan S, Sundararajan N, Senthil Kumar C, & Karpakavalli M. (2020). Synthesis, Characterization and Anti-epileptic Activity of Thiohydantoin Derivatives. International Journal of Research in Pharmaceutical Sciences, 11(4), 6490-6494.