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The modern medicine gets up a massive hike in the treatment of various ailments but scarcely any drugs having to stimulate liver activity, offering tutelage to the liver from any harm or promote the palingenesis of hepatic cells. However, a variety of herbal drugs applied in the conventional system of medicine for liver efficiency. Therefore, rhizome of Curcuma amada (Family: Zingiberaceae) are selected to allocate the hepatoprotective activity in scientifically approbate experimental models. This study is an effort to explore the 50% ethanolic extract of rhizome of Curcuma amada (CAE) in a different experimental model for hepatoprotective activities and in vitro antioxidant. 50% ethanolic extract of Curcuma amada (CAE) (100 and 200mg/kg) hepatoprotective efficiency was examined against paracetamol (1000 mg/kg) induced hepatotoxicity, elevated hepatic enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), total bilirubin direct bilirubin content in the serum. Moreover, CAE induced antioxidant protection against hepatotoxic disservice of paracetamol was estimated by evaluating several antioxidative biomarkers such as reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in the blood serum by using spectrophotometric analysis. It could be concluded that the rhizome of C. amada possesses an intense antioxidant property. Its active principle wipeout free radicals and strive a tutelary impact against oxidative harm induced to cellular macromolecules. 50% ethanolic extract of C. amada (CAE) is tenable to amplify and maintain the working of hepatic enzymes implicated in detention of ROS.
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