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The present study was designed to analyse energy-optimised structure primarily based pharmacophore virtual screening and high score compound was elect and used for hypolipidemic activity in rat fed with high-fat diet. Supported the e-pharmacophore virtual screening analysis discovered that the one in every of the compound particularly leucocyanidin has been elect for the hypolipidemic activities. In the treatment of Leucocyanidin group of animals fed with HFD was considerable reduction within the body weight compared to HFD fed cluster of animals. The enlarged the levels of TC, TG, phospholipids, LDL-C and VLDL-C were noticed in group 2 animals (HFD). When the activity of leucocyanidin (15mg per weight unit body weight per day) showed a major (p<0.001) decrement in plasma and TC, TG, phospholipids, LDL-C and VLDL-C in conjunction with an increment within the High-density lipoprotein-C compared with group 2 animals(HFD). Taking under consideration the outcomes, we tend to over that leucocyanidin may be a considerably hypolipidemic agent having preventive and curative activity against lipidemia.