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Oral squamous cell carcinoma is one of the most common malignancy worldwide. It stands in the sixth position in the worldwide malignancies. It is the major cause of death in the world. This also accounts for many head and neck cancers. Theoretically, it should mostly be preventable and detectable at a very early stage. The factors that can increase the risk of OSCC include heavy alcohol use, usage of tobacco, including cigarettes, excessive sun exposure to the lips and even a weakened immune system. 30 OSCC patients and 30 healthy individuals from the OP of Saveetha Dental College. Serum samples were analyzed for the LDH status by using the kit method in autoanalyzer. There is a significant increase in Lipid dehydrogenase levels, i.e. (p<0.005) levels present in OSCC patients when compared with healthy controls, by the influence of OSCC on LDH metabolism. Our findings suggest that assessment of LDH can be used as an effective biochemical diagnostic tool for the manifestation of OSCC and another type of malignancy in patients.
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