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To determine the level of trace elements especially copper in oral submucous fibrosis. The objective of the study is to evaluate the levels of circulating trace elements especially copper in oral submucous fibrosis. 30 OSMF patients and 30 healthy individuals from the OPD of Saveetha Dental College. Serum samples were analyzed for serum Copper level DiBrom-PAESA method using ERBA CHEM 5 plus analyzer. There is a highly significant increase in copper levels (p<0.001) in OSMF patients compared to controls, by the influence of OSMF on metabolisms. Our findings suggest that increased Copper values can be used as a diagnostic marker for the manifestation of OSMF.
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