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Stress is the causative factor for various diseases and disorders faced by the majority of the diseased population. The leaves of (S. ) are attributed to properties as per literature. The S. extract as tested for activity in animals. The study deals with the evaluation of S. extract for activity using cold immobilization stress. The S. extract (200 and 400 mg/kg) was administered to treatment groups 1 hour before stress methods for ten consecutive days. Induction of the stress procedure was repeated for ten days. Rats fasted overnight on 10th days, On 11th days the blood was collected from the retro-orbital vein for biochemical estimation under . Liver function profiles (SGOT, SGPT, and ALP), lipid profiles (TC, TG, HDL, LDL, and VLDL), differential leukocyte count (, eosinophils, lymphocyte, and ), and organs weight (adrenal gland, spleen, liver, and kidney) were evaluation parameters of activity in thecold immobilization stress. The dose group 400 mg/kg p.o.of S. extract for activity in cold immobilization showed significant variation (P< 0.1) when is compared with the stress control group. Therefore, it was revealed that S. extract showed potential activity.
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