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According to WHO international and national status, Central Nervous System (CNS) problems (neurological disorders: Alzheimers, dementia, epilepsy, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson’s disease, stroke and traumatic brain injuries) are getting worse day by day because of lifestyle, environmental imbalance and genetic problems. In 2015 WHO reported that the prevalence of CNS problems is 27.8 in 1000 and 3 people in every 100 are facing any of these CNS problems. However, unfortunately, chemically synthesized drugs used to control these problems in patients poses side effects, and therefore we need natural neuroprotective agents to avoid such complications. Syzygium cumini is herbal, a medicinal plant with reported medicinal properties in various traditional and modern medicines. Plant phytochemicals from stem bark, leaves, flowers, fruits and seeds of Syzygium cumini were using to treat many diseases in modern medicine also. So far, it is used mostly to treat diabetes mellitus, pain, inflammation, ulcers, and diarrhea, and in the recent studies, it was proven that Syzygium cumini could be used as chemopreventive, radioprotective and antineoplastic. Although the therapeutic efficacy of SZ is studied well for many systemic diseases including diabetes, much needs to be explored on its role in neurological diseases. The phytochemicals present in different parts of SZ were showing evidence that it can show neuroprotection effectively. Those phytochemicals which were already studied as neuroprotection in them, a fine number of those phytochemicals are present in Syzygium cumini. It is intimating us that Syzygium cumini can be used as an effective neuroprotective natural medicine. In this review, we elaborated there may be a possibility of potentially effective treatment with different phytochemical that has the neuroprotective effect in one plant.
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