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Abstract

Obesity, as defined by WHO is an abnormal or excessive fat accumulation that may impair health. is directly proportional to the resultant impact of genetic, metabolic, environment, and culture issues. The leading cause of obesity is an energy imbalance between calories consumed and calories exhausted. To design and optimize SNEDDS formulation by the development of SNEDDS with an appropriate quantity of oil, and with the factorial approach. A series of SNEDDS formulations for was prepared based on solubility studies, pseudo ternary phase diagram and visual observation. was added inaccurately weighed amount of oil into a screw-capped glass vial and heated in a water bath at 40ºC. The and were added to the oily mixture and stirred with a magnetic bar. The formulation was further for 15 minutes and stored at room temperature. From the result of evaluation parameters such as emulsification time 6±1s, % transmittance 94.01±1.5%, drug Loading 99.89%±0.56%, Index 0.47±0.01 and 0.211±0.02, Globulesize99±6 nm, Zeta potential -28.12 and -24.5 , The , Freeze-thaw cycle, Heating-cooling cycle showed no signs of phase separation, Viscosity 132.4±0m Pa.s, drug release 99.25% within 90 minutes, drug release follows Korsmeyer-Peppas model mechanism, n value was found to be1.083 hence it can be postulated formulation F-6 followed the or anomalous release and P-value for factors emulsification time, % transmittance and % drug release was found less than 0.0500 and hence it was concluded formulation F-6 an optimized formulation.

Keywords

Obesity SNEDDS Orlistat Magic Pills

Article Details

How to Cite
Amisha Vyas, Anupama Diwan, & Rupali Sharma. (2020). Design, Optimization and Evaluation of Snedds Based System for Orlistat: A Quality by Design Approach With 23 Factorial. International Journal of Research in Pharmaceutical Sciences, 11(4), 5517-5532. https://doi.org/10.26452/ijrps.v11i4.3186