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Abstract

Channa micropeltes is a local peatland water species which has been utilized as an alternative of Channa striata among South Kalimantan population to anticipate the scarcity of Haruan species. Channa micropeltes originate from the same family of Channa striata in which both fishes contain albumin. Albumin is proven to accelerate wound healing, thus can be produced as capsules. The capsulate form of Channa micropeltes extract will later be deployed as an alternative herbal medicine for the acceleration of mucosal wound healing. Nevertheless, a study of a hepatological profile is pivotal to assess the safety of its consumption. The present study aimed to analyze the effect of Channa micropeltes extracts capsulate oral administration at 0.7 g dosage on SGOT and SGPT level of Wistar rat liver. This was a real experimental study with post-test only and control group design. The samples comprised of 12 rats which were distributed into three groups namely a treatment group of 0.7 g Channa extract capsulate, a positive control group of 0.7 g Channa striata extract and a negative control group without any treatment for 28 days. The level of SGOT and SGPT were 19.41 IU/L and 29.52 IU/L in Channa micropeltes treatment group, 31.95 IU/L and 28.71 IU/L in the positive control group of 0.7 g Channa striata extract, 25.07 IU/L and 18.90 IU/L in the negative control group. Hence, there is no effect of Channa micropeltes extract capsulate oral administration at 0.7 g dosage on SGOT and SGPT level of Wistar rat liver.

Keywords

Albumin Channa micropeltes Hepar SGOT SGPT

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How to Cite
Amy Nindia Carabelly, Deby Kania Tri Putri, Nadya Rezki, & Maharani Laillyza Apriasari. (2020). SGOT and SGPT level of Wistar rat after the administration of Channa micropeltes extract. International Journal of Research in Pharmaceutical Sciences, 11(4), 5415-5421. https://doi.org/10.26452/ijrps.v11i4.3169