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The purpose of this project is to study the anti-diabetic effect of on a diabetic rat model. A total of Twenty male Sprague rats were used and it randomly distributed into four groups which are Group I: , Group II: negative control, Group III: and Group IV: and . In diabetic model were induced with via injection at the dosage of 65mg/kg. and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p<0.05) and group IV (11.34 ±3.67, p<0.05) were significantly decreased. Meanwhile, the for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p<0.05) significantly. The present study shows that the and the combination of and lowered blood glucose level and enhanced insulin secretion.


Diabetic rat Diphenhydramine Hydrochloride Glibenclamide Streptozotocin

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How to Cite
Pang Jyh Chayng, Nurul Ain, Kaswandi Md Ambia, & Rahim Md Noah. (2020). Anti-diabetic activity of diphenhydramine in diabetic rats. International Journal of Research in Pharmaceutical Sciences, 11(4), 5067-5070.