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The Tamoxifen (TAM) is an effective anticancer drug; it is a hormonal treatment against estrogen necessary for the growth of cancer cells. The study was conducted to estimate the effects of TAM on some physiological and histological parameters. We used for 40 rats of the strain albino rat [Rattus norvegicus] divided into four groups. A total of three groups were given different TAM doses (30, 40, 50mg/kg) of the body weight four times a week during 10 weeks period. The control group was injected with physiological solution (Normal Saline 0.9%). At the end of dosage duration, the blood was collected for some biochemical parameters (kidney functions) investigation. The test results showed significant differences in the treated groups as three groups revealed a significant increase in Urea, Uric Acid, Creatinine levels. The kidney tissues histopathological examination of in the TAM groups showed histological changes which increased in accordance with elevated doses administration in comparison with the control group. The histological changes were inflammatory cells infiltration, blood congestion, pyknic and necrotic nucleus in glomerulus with massive degeneration in epithelial of renal tubules, and deformed of architecture of renal tissue. In addition, massive infiltration of mononucleosis adjacent dilated blood vessels with hemorrhage in tubule and necrosis of tubules that exhibited pyknic and necrotic nucleus in glomerulus as well. As well as the exhibited small granulomatous lesion with large dilated of blood vessels and necrotic tubules with great granulomatous trauma containing from accumulation of macrophages and lymphocytes with vacuolar degeneration of tubules and massive necrotic of glomerulus with thickness of bowman capsule.
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