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The study aimed to isolate and identify the phytochemical components of Polyalthia lateriflora leaves and evaluate the antimicrobial activity. Six well-known compounds, including three triterpene lupeol (1) betulinic acid (2), β-Sitosterol-β-D-glucoside (3) and three oxoaporphine alkaloids O-methylmoschotaline (4), liriodenine (5) and atherosperminine (6). Structural elucidation of compounds were established through spectroscopic techniques such as 1D and 2D NMR (1H and 13C, DEPT, COSY, NOESY, HMBC, HMQC), IR and LC-MS. The isolated compounds and crude extracted were tested for their antibacterial potential against several microorganisms including P. aeruginosa, E. coli, s, S. aureus, B. subtilis and Saccharomyces cerevisiae and its showed significant inhibition toward the organisms species with different concentration range.


Alkaloid Triterpene Antimicrobial Bacterial Yeast

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Saripah Salbiah Syed Abdul Azziz, Ahmed Kareem Obaid Aldulaimi, Saadon Abdulla Aowda, Yuhanis Mhd Bakri, Ali Arkan Majhool, Rawdha Mohammed Ibraheem, Tamara Kareem Obaid Aldulaimi, Hamidah Idris, Chee Fah Wong, Khalijah Awang, Marc Litaudon, & Fauziah Abdullah. (2020). Secondary Metabolites from Leaves of Polyalthia lateriflora and Their Antimicrobial Activity. International Journal of Research in Pharmaceutical Sciences, 11(3), 4353-4358.